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Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance

BACKGROUND: Artemisinin-based combination therapies are the first line of treatment for Plasmodium falciparum infections worldwide, but artemisinin resistance has risen rapidly in Southeast Asia over the past decade. Mutations in the kelch13 gene have been implicated in this resistance. We used long...

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Τόπος έκδοσης:	Genome Biol
Κύριοι συγγραφείς:	Cerqueira, Gustavo C., Cheeseman, Ian H., Schaffner, Steve F., Nair, Shalini, McDew-White, Marina, Phyo, Aung Pyae, Ashley, Elizabeth A., Melnikov, Alexandre, Rogov, Peter, Birren, Bruce W., Nosten, François, Anderson, Timothy J. C., Neafsey, Daniel E.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BioMed Central 2017
Θέματα:	Research
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5410087/ https://ncbi.nlm.nih.gov/pubmed/28454557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1204-4
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Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance

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