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Pooled Sequencing and Rare Variant Association Tests for Identifying the Determinants of Emerging Drug Resistance in Malaria Parasites

We explored the potential of pooled sequencing to swiftly and economically identify selective sweeps due to emerging artemisinin (ART) resistance in a South-East Asian malaria parasite population. ART resistance is defined by slow parasite clearance from the blood of ART-treated patients and mutatio...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Biol Evol
Prif Awduron: Cheeseman, Ian H., McDew-White, Marina, Phyo, Aung Pyae, Sriprawat, Kanlaya, Nosten, François, Anderson, Timothy J.C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4379400/
https://ncbi.nlm.nih.gov/pubmed/25534029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msu397
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