Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance

BACKGROUND: Artemisinin-based combination therapies are the first line of treatment for Plasmodium falciparum infections worldwide, but artemisinin resistance has risen rapidly in Southeast Asia over the past decade. Mutations in the kelch13 gene have been implicated in this resistance. We used long...

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Bibliographic Details
Published in:Genome Biol
Main Authors: Cerqueira, Gustavo C., Cheeseman, Ian H., Schaffner, Steve F., Nair, Shalini, McDew-White, Marina, Phyo, Aung Pyae, Ashley, Elizabeth A., Melnikov, Alexandre, Rogov, Peter, Birren, Bruce W., Nosten, François, Anderson, Timothy J. C., Neafsey, Daniel E.
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410087/
https://ncbi.nlm.nih.gov/pubmed/28454557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1204-4
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