Genetic architecture of artemisinin-resistant Plasmodium falciparum

We report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, we identified at least 20 mutations in kelch13 (PF3D7_1343700) affecting the encoded propeller and BTB/POZ domains,...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Miotto, Olivo, Amato, Roberto, Ashley, Elizabeth A, MacInnis, Bronwyn, Almagro-Garcia, Jacob, Amaratunga, Chanaki, Lim, Pharath, Mead, Daniel, Oyola, Samuel O, Dhorda, Mehul, Imwong, Mallika, Woodrow, Charles, Manske, Magnus, Stalker, Jim, Drury, Eleanor, Campino, Susana, Amenga-Etego, Lucas, Thanh, Thuy-Nhien Nguyen, Tran, Hien Tinh, Ringwald, Pascal, Bethell, Delia, Nosten, Francois, Phyo, Aung Pyae, Pukrittayakamee, Sasithon, Chotivanich, Kesinee, Chuor, Char Meng, Nguon, Chea, Suon, Seila, Sreng, Sokunthea, Newton, Paul N, Mayxay, Mayfong, Khanthavong, Maniphone, Hongvanthong, Bouasy, Htut, Ye, Han, Kay Thwe, Kyaw, Myat Phone, Faiz, Md Abul, Fanello, Caterina I, Onyamboko, Marie, Mokuolu, Olugbenga A, Jacob, Christopher G, Takala-Harrison, Shannon, Plowe, Christopher V, Day, Nicholas P, Dondorp, Arjen M, Spencer, Chris C A, McVean, Gilean, Fairhurst, Rick M, White, Nicholas J, Kwiatkowski, Dominic P
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545236/
https://ncbi.nlm.nih.gov/pubmed/25599401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3189
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