A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages

Macrophages produce genotoxic agents, such as reactive oxygen and nitrogen species, that kill invading pathogens. Here we show that these agents activate the DNA damage response (DDR) kinases ATM and DNA-PKcs through the generation of double stranded breaks (DSBs) in murine macrophage genomic DNA. I...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Morales, Abigail J, Carrero, Javier A, Hung, Putzer J, Tubbs, Anthony T, Andrews, Jared M, Edelson, Brian T, Calderon, Boris, Innes, Cynthia L, Paules, Richard S, Payton, Jacqueline E, Sleckman, Barry P
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2017
Pynciau:
Immunology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409825/
https://ncbi.nlm.nih.gov/pubmed/28362262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24655
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