A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages

Macrophages produce genotoxic agents, such as reactive oxygen and nitrogen species, that kill invading pathogens. Here we show that these agents activate the DNA damage response (DDR) kinases ATM and DNA-PKcs through the generation of double stranded breaks (DSBs) in murine macrophage genomic DNA. I...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Morales, Abigail J, Carrero, Javier A, Hung, Putzer J, Tubbs, Anthony T, Andrews, Jared M, Edelson, Brian T, Calderon, Boris, Innes, Cynthia L, Paules, Richard S, Payton, Jacqueline E, Sleckman, Barry P
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409825/
https://ncbi.nlm.nih.gov/pubmed/28362262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24655
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