A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes

The overwhelming amount of genetic alterations identified through cancer genome sequencing requires complementary approaches to interpret their significance and interactions. We developed a novel whole-body insertional mutagenesis screen in mice, designed for the discovery of Pten-cooperating tumor...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Genet
Egile Nagusiak: de la Rosa, Jorge, Weber, Julia, Friedrich, Mathias Josef, Li, Yilong, Rad, Lena, Ponstingl, Hannes, Liang, Qi, de Quirós, Sandra Bernaldo, Noorani, Imran, Metzakopian, Emmanouil, Strong, Alexander, Li, Meng Amy, Astudillo, Aurora, Fernández-García, María Teresa, Fernández-García, María Soledad, Hoffman, Gary J., Fuente, Rocío, Vassiliou, George S., Rad, Roland, López-Otín, Carlos, Bradley, Allan, Cadiñanos, Juan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409503/
https://ncbi.nlm.nih.gov/pubmed/28319090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3817
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