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A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1

Higher-order nucleic acid structures called G-quadruplexes (G4s, G4 structures) can form in guanine-rich regions of both DNA and RNA and are highly thermally stable. There are >375,000 putative G4-forming sequences in the human genome, and they are enriched in promoter regions, untranslated regio...

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Detalhes bibliográficos
Publicado no:J Vis Exp
Main Authors: Routh, Eric D., Creacy, Steven D., Beerbower, Peter E., Akman, Steven A., Vaughn, James P., Smaldino, Philip J.
Formato: Artigo
Idioma:Inglês
Publicado em: MyJove Corporation 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409278/
https://ncbi.nlm.nih.gov/pubmed/28362374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/55496
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