G4 Resolvase 1 Binds Both DNA and RNA Tetramolecular Quadruplex with High Affinity and Is the Major Source of Tetramolecular Quadruplex G4-DNA and G4-RNA Resolving Activity in HeLa Cell Lysates

Quadruplex structures that result from stacking of guanine quartets in nucleic acids possess such thermodynamic stability that their resolution in vivo is likely to require specific recognition by specialized enzymes. We previously identified the major tetramolecular quadruplex DNA resolving activit...

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Detalhes bibliográficos
Main Authors: Creacy, Steven D., Routh, Eric D., Iwamoto, Fumiko, Nagamine, Yoshikuni, Akman, Steven A., Vaughn, James P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
RNA: Processing and Catalysis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596407/
https://ncbi.nlm.nih.gov/pubmed/18842585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806277200
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