Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3’-Tail Sequences Are Sufficient for Tight and Complete Binding

Ends of human chromosomes consist of the six nucleotide repeat d[pTTAGGG](n) known as telomeric DNA, which protects chromosomes. We have previously shown that the DHX36 gene product, G4 Resolvase 1 (G4R1), binds parallel G-quadruplex (G4) DNA with an unusually tight apparent K(d). Recent work associ...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Smaldino, Philip J., Routh, Eric D., Kim, Jung H., Giri, Banabihari, Creacy, Steven D., Hantgan, Roy R., Akman, Steven A., Vaughn, James P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501837/
https://ncbi.nlm.nih.gov/pubmed/26172836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132668
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