The ROCK Inhibitor Fasudil Prevents Chronic Restraint Stress-Induced Depressive-Like Behaviors and Dendritic Spine Loss in Rat Hippocampus

BACKGROUND: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression. These morphological changes imply modifications in dendritic cytoskeleton. Rho GTPases are regulators of actin...

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Vydáno v:Int J Neuropsychopharmacol
Hlavní autoři: García-Rojo, Gonzalo, Fresno, Cristóbal, Vilches, Natalia, Díaz-Véliz, Gabriela, Mora, Sergio, Aguayo, Felipe, Pacheco, Aníbal, Parra-Fiedler, Nicolás, Parra, Claudio S., Rojas, Paulina S., Tejos, Macarena, Aliaga, Esteban, Fiedler, Jenny L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Regular Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409106/
https://ncbi.nlm.nih.gov/pubmed/27927737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyw108
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