Mapping eQTLs with RNA-seq reveals novel susceptibility genes, non-coding RNAs and alternative-splicing events in systemic lupus erythematosus

Studies attempting to functionally interpret complex-disease susceptibility loci by GWAS and eQTL integration have predominantly employed microarrays to quantify gene-expression. RNA-Seq has the potential to discover a more comprehensive set of eQTLs and illuminate the underlying molecular consequen...

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Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Odhams, Christopher A., Cortini, Andrea, Chen, Lingyan, Roberts, Amy L., Viñuela, Ana, Buil, Alfonso, Small, Kerrin S., Dermitzakis, Emmanouil T., Morris, David L., Vyse, Timothy J., Cunninghame Graham, Deborah S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Association Studies Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409091/
https://ncbi.nlm.nih.gov/pubmed/28062664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw417
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