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Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease

Genome-wide association studies have identified hundreds of risk loci for autoimmune disease, yet only a minority (~25%) share genetic effects with changes to gene expression (eQTLs) in immune cells. RNA-Seq based quantification at whole-gene resolution, where abundance is estimated by culminating e...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Genet
Egile Nagusiak: Odhams, Christopher A., Cunninghame Graham, Deborah S., Vyse, Timothy J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695635/
https://ncbi.nlm.nih.gov/pubmed/29059182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007071
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