High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring

Methylenetetrahydrofolate reductase (MTHFR) generates methyltetrahydrofolate for methylation reactions. Severe MTHFR deficiency results in homocystinuria and neurologic impairment. Mild MTHFR deficiency (677C > T polymorphism) increases risk for complex traits, including neuropsychiatric disorder...

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Publicado no:Hum Mol Genet
Main Authors: Bahous, Renata H., Jadavji, Nafisa M., Deng, Liyuan, Cosín-Tomás, Marta, Lu, Jessica, Malysheva, Olga, Leung, Kit-Yi, Ho, Ming-Kai, Pallàs, Mercè, Kaliman, Perla, Greene, Nicholas D.E., Bedell, Barry J., Caudill, Marie A., Rozen, Rima
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409086/
https://ncbi.nlm.nih.gov/pubmed/28069796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx004
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