High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice(1)(2)(3)(4)(5)

Background: Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are largely unknown. Methylenetetrahydrofolate reductase (MTHFR) provides methyl donors for S-adenosylmethio...

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Detalhes bibliográficos
Publicado no:Am J Clin Nutr
Main Authors: Christensen, Karen E, Mikael, Leonie G, Leung, Kit-Yi, Lévesque, Nancy, Deng, Liyuan, Wu, Qing, Malysheva, Olga V, Best, Ana, Caudill, Marie A, Greene, Nicholas DE, Rozen, Rima
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Nutrition 2015
Assuntos:
Gene-Nutrient Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340065/
https://ncbi.nlm.nih.gov/pubmed/25733650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/ajcn.114.086603
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