Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients

Recently-developed cystic fibrosis transmembrane conductance regulator (CFTR)-modulating drugs correct surface expression and/or function of the mutant CFTR channel in subjects with cystic fibrosis (CF). Identification of subjects that may benefit from these drugs is challenging because of the exten...

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Dades bibliogràfiques
Publicat a:J Vis Exp
Autors principals: Boj, Sylvia F., Vonk, Annelotte M., Statia, Marvin, Su, Jinyi, Dekkers, Johanna F., Vries, Robert R. G., Beekman, Jeffrey M., Clevers, Hans
Format: Artigo
Idioma:Inglês
Publicat: MyJove Corporation 2017
Matèries:
Medicine
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408767/
https://ncbi.nlm.nih.gov/pubmed/28287550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/55159
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