Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Human CD8+ cytotoxic T lymphocytes (CTLs) are known to play an important role in tumor control. In order to carry out this function, the cell surface-expressed T-cell receptor (TCR) must functionally recognize human leukocyte antigen (HLA)-restricted tumor-derived peptides (pHLA). However, we and ot...

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Detalhes bibliográficos
Publicado no:J Vis Exp
Main Authors: MacLachlan, Bruce J., Greenshields-Watson, Alexander, Mason, Georgina H, Schauenburg, Andrea J, Bianchi, Valentina, Rizkallah, Pierre J, Sewell, Andrew K, Fuller, Anna, Cole, David K
Formato: Artigo
Idioma:Inglês
Publicado em: MyJove Corporation 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408581/
https://ncbi.nlm.nih.gov/pubmed/28287509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/54991
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