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Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects

BACKGROUND: Promiscuity in molecular interactions between small-molecules, including drugs, and proteins is widespread. Such unintended interactions can be exploited to suggest drug repurposing possibilities as well as to identify potential molecular mechanisms responsible for observed side-effects....

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:BMC Pharmacol Toxicol
मुख्य लेखकों: Chartier, Matthieu, Morency, Louis-Philippe, Zylber, María Inés, Najmanovich, Rafael J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: BioMed Central 2017
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408384/
https://ncbi.nlm.nih.gov/pubmed/28449705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-017-0128-7
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