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Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects
BACKGROUND: Promiscuity in molecular interactions between small-molecules, including drugs, and proteins is widespread. Such unintended interactions can be exploited to suggest drug repurposing possibilities as well as to identify potential molecular mechanisms responsible for observed side-effects....
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| Pubblicato in: | BMC Pharmacol Toxicol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5408384/ https://ncbi.nlm.nih.gov/pubmed/28449705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-017-0128-7 |
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