Loss of PTEN associated with resistance to anti-PD-1 checkpoint blockade therapy in metastatic uterine leiomyosarcoma

Response to immune checkpoint blockade in mesenchymal tumors is poorly characterized, but immunogenomic dissection of these cancers may inform immunotherapy mediators. We identified a treatment-naïve patient with metastatic uterine leiomyosarcoma who experienced complete tumor remission for >2 ye...

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Pubblicato in:Immunity
Autori principali: George, Suzanne, Miao, Diana, Demetri, George D., Adeegbe, Dennis, Rodig, Scott J., Shukla, Sachet, Lipschitz, Mikel, Amin-Mansour, Ali, Raut, Chandrajit P., Carter, Scott L., Hammerman, Peter, Freeman, Gordon J., Wu, Catherine J., Ott, Patrick A., Wong, Kwok-Kin, Van Allen, Eliezer M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408320/
https://ncbi.nlm.nih.gov/pubmed/28228279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.02.001
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