Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia

Bioassay-guided separation of a lipophilic extract of the crinoid Alloeocomatella polycladia, inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates 1–4. The structures of the aromatics were elucidated by spectroscopic analysi...

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Veröffentlicht in:Mar Drugs
Hauptverfasser: Hermawan, Idam, Furuta, Atsushi, Higashi, Masahiro, Fujita, Yoshihisa, Akimitsu, Nobuyoshi, Yamashita, Atsuya, Moriishi, Kohji, Tsuneda, Satoshi, Tani, Hidenori, Nakakoshi, Masamichi, Tsubuki, Masayoshi, Sekiguchi, Yuji, Noda, Naohiro, Tanaka, Junichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408263/
https://ncbi.nlm.nih.gov/pubmed/28398249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md15040117
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