Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1

Opioids are very effective analgesics, but they are also highly addictive. Methadone is used to treat opioid dependence (OD), acting as a selective agonist at the μ-opioid receptor encoded by the gene OPRM1. Determining the optimal methadone maintenance dose is time-consuming; currently, no biomarke...

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Опубликовано в: :Mol Psychiatry
Главные авторы: Smith, Andrew H., Jensen, Kevin P., Li, Jin, Nunez, Yaira, Farrer, Lindsay A., Hakonarson, Hakon, Cook-Sather, Scott D., Kranzler, Henry R., Gelernter, Joel
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407902/
https://ncbi.nlm.nih.gov/pubmed/28115739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2016.257
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