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Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1
Opioids are very effective analgesics, but they are also highly addictive. Methadone is used to treat opioid dependence (OD), acting as a selective agonist at the μ-opioid receptor encoded by the gene OPRM1. Determining the optimal methadone maintenance dose is time-consuming; currently, no biomarke...
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| Publié dans: | Mol Psychiatry |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5407902/ https://ncbi.nlm.nih.gov/pubmed/28115739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2016.257 |
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