Mycobacterium marinum antagonistically induces an autophagic response while repressing the autophagic flux in a TORC1- and ESX-1-dependent manner

Autophagy is a eukaryotic catabolic process also participating in cell-autonomous defence. Infected host cells generate double-membrane autophagosomes that mature in autolysosomes to engulf, kill and digest cytoplasmic pathogens. However, several bacteria subvert autophagy and benefit from its machi...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Cardenal-Muñoz, Elena, Arafah, Sonia, López-Jiménez, Ana Teresa, Kicka, Sébastien, Falaise, Alexandra, Bach, Frauke, Schaad, Olivier, King, Jason S., Hagedorn, Monica, Soldati, Thierry
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407849/
https://ncbi.nlm.nih.gov/pubmed/28414774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006344
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