Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis

BACKGROUND: A host defense function for Alkaline phosphatases (ALPs) is suggested by the contribution of intestinal ALP to detoxifying bacterial lipopolysaccharide (endotoxin) in animal models in vivo and the elevation of ALP activity following treatment of human cells with inflammatory stimuli in v...

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Udgivet i:PLoS One
Main Authors: Pettengill, Matthew, Matute, Juan D., Tresenriter, Megan, Hibbert, Julie, Burgner, David, Richmond, Peter, Luis Millán, José, Ozonoff, Al, Strunk, Tobias, Currie, Andrew, Levy, Ofer
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407836/
https://ncbi.nlm.nih.gov/pubmed/28448526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0175936
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