Sildenafil Prevents Podocyte Injury via PPAR-γ–Mediated TRPC6 Inhibition

Transient receptor potential channel C6 (TRPC6) gain-of-function mutations and increased TRPC6 expression in podocytes induce glomerular injury and proteinuria. Sildenafil reduces TRPC6 expression and activity in nonrenal cell types, although the mechanism is unknown. Peroxisome proliferator–activat...

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Dettagli Bibliografici
Pubblicato in:J Am Soc Nephrol
Autori principali: Sonneveld, Ramon, Hoenderop, Joost G., Isidori, Andrea M., Henique, Carole, Dijkman, Henry B., Berden, Jo H., Tharaux, Pierre-Louis, van der Vlag, Johan, Nijenhuis, Tom
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2017
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407711/
https://ncbi.nlm.nih.gov/pubmed/27895156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015080885
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