Sildenafil Prevents Podocyte Injury via PPAR-γ–Mediated TRPC6 Inhibition

Transient receptor potential channel C6 (TRPC6) gain-of-function mutations and increased TRPC6 expression in podocytes induce glomerular injury and proteinuria. Sildenafil reduces TRPC6 expression and activity in nonrenal cell types, although the mechanism is unknown. Peroxisome proliferator–activat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Soc Nephrol
Prif Awduron: Sonneveld, Ramon, Hoenderop, Joost G., Isidori, Andrea M., Henique, Carole, Dijkman, Henry B., Berden, Jo H., Tharaux, Pierre-Louis, van der Vlag, Johan, Nijenhuis, Tom
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Nephrology 2017
Pynciau:
Basic Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407711/
https://ncbi.nlm.nih.gov/pubmed/27895156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015080885
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