Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain

BACKGROUND: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord. Because the epigenetic mechanisms are typically long-lasting, we hypothesized that analgesia could ou...

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Detalhes bibliográficos
Publicado no:Mol Pain
Main Authors: Notartomaso, Serena, Mascio, Giada, Bernabucci, Matteo, Zappulla, Cristina, Scarselli, Pamela, Cannella, Milena, Imbriglio, Tiziana, Gradini, Roberto, Battaglia, Giuseppe, Bruno, Valeria, Nicoletti, Ferdinando
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407675/
https://ncbi.nlm.nih.gov/pubmed/28326943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806917697009
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