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N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors

BACKGROUND: Pharmacological activation of type-2 metabotropic glutamate receptors (mGlu2 receptors) causes analgesia in experimental models of inflammatory and neuropathic pain. Presynaptic mGlu2 receptors are activated by the glutamate released from astrocytes by means of the cystine/glutamate anti...

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Bibliografiske detaljer
Main Authors: Bernabucci, Matteo, Notartomaso, Serena, Zappulla, Cristina, Fazio, Francesco, Cannella, Milena, Motolese, Marta, Battaglia, Giuseppe, Bruno, Valeria, Gradini, Roberto, Nicoletti, Ferdinando
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543227/
https://ncbi.nlm.nih.gov/pubmed/23088864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-8-77
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