Bile Acids Initiate Lineage‐Addicted Gastroesophageal Tumorigenesis by Suppressing the EGF Receptor‐AKT Axis

While bile acids are a risk factor for tumorigenesis induced by reflux disease, the mechanisms by which they contribute to neoplasia remain undefined. Here, we reveal that in gastroesophageal junction (GEJ) cells bile acids activate a tissue‐specific developmental program defining the intestinal epi...

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Detalhes bibliográficos
Publicado no:Clin Transl Sci
Main Authors: Gong, Li, Debruyne, Philip R., Witek, Matthew, Nielsen, Karl, Snook, Adam, Lin, Jieru E., Bombonati, Alessandro, Palazzo, Juan, Schulz, Stephanie, Waldman, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Inc 2009
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407481/
https://ncbi.nlm.nih.gov/pubmed/20443907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1752-8062.2009.00131.x
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