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Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development
Polycomb group proteins form two main complexes, PRC2 and PRC1, which generally coregulate their target genes. Here, we show that PRC1 components act as neoplastic tumor suppressors independently of PRC2 function. By mapping the distribution of PRC1 components and the histone H3K27me3 mark, we ident...
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| Publicado no: | Nat Genet |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5407438/ https://ncbi.nlm.nih.gov/pubmed/27643538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3671 |
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