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Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development
Polycomb group proteins form two main complexes, PRC2 and PRC1, which generally coregulate their target genes. Here, we show that PRC1 components act as neoplastic tumor suppressors independently of PRC2 function. By mapping the distribution of PRC1 components and the histone H3K27me3 mark, we ident...
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| Yayımlandı: | Nat Genet |
|---|---|
| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5407438/ https://ncbi.nlm.nih.gov/pubmed/27643538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3671 |
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