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Probing the Dynamics of Clot-Bound Thrombin at Venous Shear Rates
In closed system models of fibrin formation, exosite-mediated thrombin binding to fibrin contributes to clot stability and is resistant to inhibition by antithrombin/heparin while still susceptible to small, active-site inhibitors. Each molecule of fibrin can bind ∼1.6 thrombin molecules at low-affi...
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| Udgivet i: | Biophys J |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Biophysical Society
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5406282/ https://ncbi.nlm.nih.gov/pubmed/28445754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.03.002 |
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