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Probing the Dynamics of Clot-Bound Thrombin at Venous Shear Rates

In closed system models of fibrin formation, exosite-mediated thrombin binding to fibrin contributes to clot stability and is resistant to inhibition by antithrombin/heparin while still susceptible to small, active-site inhibitors. Each molecule of fibrin can bind ∼1.6 thrombin molecules at low-affi...

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Détails bibliographiques
Publié dans:Biophys J
Auteurs principaux: Haynes, Laura M., Orfeo, Thomas, Mann, Kenneth G., Everse, Stephen J., Brummel-Ziedins, Kathleen E.
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5406282/
https://ncbi.nlm.nih.gov/pubmed/28445754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.03.002
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