Aging increases cell-to-cell transcriptional variability upon immune stimulation

Aging is characterized by progressive loss of physiological and cellular functions, but the molecular basis of this decline remains unclear. We explored how aging impacts transcriptional dynamics using single-cell RNA-sequencing of unstimulated and stimulated naive and effector memory CD4(+) T cells...

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Publicado no:Science
Main Authors: Martinez-Jimenez, Celia Pilar, Eling, Nils, Chen, Hung-Chang, Vallejos, Catalina A., Kolodziejczyk, Aleksandra A., Connor, Frances, Stojic, Lovorka, Rayner, Timothy F., Stubbington, Michael J.T., Teichmann, Sarah A., de la Roche, Maike, Marioni, John C., Odom, Duncan T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405862/
https://ncbi.nlm.nih.gov/pubmed/28360329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aah4115
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