Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis

Most human aneuploidies originate maternally, due in part to the presence of highly stringent checkpoints during male meiosis. Indeed, male sterility is common among aneuploid mice used to study chromosomal abnormalities, and male germline transmission of exogenous DNA has been rarely reported. Here...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ernst, Christina, Pike, Jeremy, Aitken, Sarah J, Long, Hannah K, Eling, Nils, Stojic, Lovorka, Ward, Michelle C, Connor, Frances, Rayner, Timothy F, Lukk, Margus, Klose, Robert J, Kutter, Claudia, Odom, Duncan T
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Genes and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161449/
https://ncbi.nlm.nih.gov/pubmed/27855777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.20235
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