Mucosal Vaccination with Heterologous Viral Vectored Vaccine Targeting Subdominant SIV Accessory Antigens Strongly Inhibits Early Viral Replication

Conventional HIV T cell vaccine strategies have not been successful in containing acute peak viremia, nor in providing long-term control. We immunized rhesus macaques intramuscularly and rectally using a heterologous adenovirus vectored SIV vaccine regimen encoding normally weakly immunogenic tat, v...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Xu, Huanbin, Andersson, Anne-Marie, Ragonnaud, Emeline, Boilesen, Ditte, Tolver, Anders, Jensen, Benjamin Anderschou Holbech, Blanchard, James L., Nicosia, Alfredo, Folgori, Antonella, Colloca, Stefano, Cortese, Riccardo, Thomsen, Allan Randrup, Christensen, Jan Pravsgaard, Veazey, Ronald S., Holst, Peter Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405164/
https://ncbi.nlm.nih.gov/pubmed/28302457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.03.003
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