Pre-Existing Vector Immunity Does Not Prevent Replication Deficient Adenovirus from Inducing Efficient CD8 T-Cell Memory and Recall Responses

Adenoviral vectors have shown a great potential for vaccine development due to their inherent ability to induce potent and protective CD8 T-cell responses. However, a critical issue regarding the use of these vectors is the existence of inhibitory immunity against the most commonly used Ad5 vector i...

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Hlavní autoři: Steffensen, Maria Abildgaard, Jensen, Benjamin Anderschou Holbech, Holst, Peter Johannes, Bassi, Maria Rosaria, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326056/
https://ncbi.nlm.nih.gov/pubmed/22514686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034884
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