Co-Expression of Tumor Antigen and Interleukin-2 From an Adenoviral Vector Augments the Efficiency of Therapeutic Tumor Vaccination

We have previously shown that for the majority of antigens, adenoviral vaccines expressing the target antigen fused to the MHC associated invariant chain (Ii) induce an accelerated, augmented, and prolonged transgene-specific CD8(+) T-cell response. Here we describe a new adenoviral vaccine vector a...

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Bibliografski detalji
Izdano u:Mol Ther
Glavni autori: Jensen, Benjamin Anderschou Holbech, Steffensen, Maria Abildgaard, Nielsen, Karen Nørgaard, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Holst, Peter Johannes
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429690/
https://ncbi.nlm.nih.gov/pubmed/25023330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.130
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