Co-Expression of Tumor Antigen and Interleukin-2 From an Adenoviral Vector Augments the Efficiency of Therapeutic Tumor Vaccination

We have previously shown that for the majority of antigens, adenoviral vaccines expressing the target antigen fused to the MHC associated invariant chain (Ii) induce an accelerated, augmented, and prolonged transgene-specific CD8(+) T-cell response. Here we describe a new adenoviral vaccine vector a...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Jensen, Benjamin Anderschou Holbech, Steffensen, Maria Abildgaard, Nielsen, Karen Nørgaard, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Holst, Peter Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429690/
https://ncbi.nlm.nih.gov/pubmed/25023330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.130
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