Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer’s Disease

Amyloid-ß (Aß) precursor protein (APP) metabolism engages neuronal endolysosomal pathways for Aß processing and secretion. In Alzheimer’s disease (AD), dysregulation of APP leads to excess Aß and neuronal dysfunction; suggesting that neuronal APP/Aß trafficking can be targeted for therapeutic gain....

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Publicat a:J Neuroimmune Pharmacol
Autors principals: Embury, Christine M, Dyavarshetty, Bhagyalaxmi, Lu, Yaman, Wiederin, Jayme L, Ciborowski, Pawel, Gendelman, Howard E, Kiyota, Tomomi
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405105/
https://ncbi.nlm.nih.gov/pubmed/27966067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-016-9721-6
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