FOXO1-AMPK-ULK1 Regulates Ethanol-induced Autophagy in Muscle by Enhanced ATG14 Association with the BECN1-PIK3C3 Complex

BACKGROUND: Excessive alcohol (EtOH) consumption causes imbalances in protein metabolism. EtOH impairs protein synthesis in C2C12 myoblasts via a FoxO1-AMPK-TSC2-mTORC1 pathway and also induces degradation. As the underlying regulatory signaling cascades for these processes are currently poorly defi...

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Detaylı Bibliyografya
Yayımlandı:Alcohol Clin Exp Res
Asıl Yazarlar: Hong-Brown, Ly Q., Brown, C. Randell, Navaratnarajah, Maithili, Lang, Charles H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404978/
https://ncbi.nlm.nih.gov/pubmed/28299793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.13377
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