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FOXO1-AMPK-ULK1 Regulates Ethanol-induced Autophagy in Muscle by Enhanced ATG14 Association with the BECN1-PIK3C3 Complex
BACKGROUND: Excessive alcohol (EtOH) consumption causes imbalances in protein metabolism. EtOH impairs protein synthesis in C2C12 myoblasts via a FoxO1-AMPK-TSC2-mTORC1 pathway and also induces degradation. As the underlying regulatory signaling cascades for these processes are currently poorly defi...
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| Publicado no: | Alcohol Clin Exp Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5404978/ https://ncbi.nlm.nih.gov/pubmed/28299793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.13377 |
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