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Capillary K(+)-sensing initiates retrograde hyperpolarization to locally increase cerebral blood flow

Blood flow into the brain is dynamically regulated to satisfy the changing metabolic requirements of neurons, but how this is accomplished has remained unclear. Here, we demonstrate a central role for capillary endothelial cells in sensing neural activity and communicating it to upstream arterioles...

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Pubblicato in:Nat Neurosci
Autori principali: Longden, Thomas A., Dabertrand, Fabrice, Koide, Masayo, Gonzales, Albert L., Tykocki, Nathan R., Brayden, Joseph E., Hill-Eubanks, David, Nelson, Mark T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404963/
https://ncbi.nlm.nih.gov/pubmed/28319610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4533
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