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Capillary K(+)-sensing initiates retrograde hyperpolarization to locally increase cerebral blood flow

Blood flow into the brain is dynamically regulated to satisfy the changing metabolic requirements of neurons, but how this is accomplished has remained unclear. Here, we demonstrate a central role for capillary endothelial cells in sensing neural activity and communicating it to upstream arterioles...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Longden, Thomas A., Dabertrand, Fabrice, Koide, Masayo, Gonzales, Albert L., Tykocki, Nathan R., Brayden, Joseph E., Hill-Eubanks, David, Nelson, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404963/
https://ncbi.nlm.nih.gov/pubmed/28319610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4533
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