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Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases
The Pim protein kinases are frequently overexpressed in prostate cancer and certain forms of leukemia and lymphoma. 5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione (4a) was identified by screening to be a Pim-1 inhibitor and was found to attenuate the autophosphorylation of tagged Pim-1 in in...
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| Vydáno v: | J Med Chem |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5404933/ https://ncbi.nlm.nih.gov/pubmed/19072652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800937p |
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