Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children

Low-dose primaquine is recommended to prevent Plasmodium falciparum malaria transmission in areas threatened by artemisinin resistance and areas aiming for malaria elimination. Community treatment campaigns with artemisinin-based combination therapy in combination with the gametocytocidal primaquine...

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Foilsithe in:Antimicrob Agents Chemother
Main Authors: Gonçalves, Bronner P., Pett, Helmi, Tiono, Alfred B., Murry, Daryl, Sirima, Sodiomon B., Niemi, Mikko, Bousema, Teun, Drakeley, Chris, ter Heine, Rob
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2017
Ábhair:
Pharmacology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404566/
https://ncbi.nlm.nih.gov/pubmed/28289025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02590-16
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