In Vivo Pharmacokinetic and Pharmacodynamic Profiles of Antofloxacin against Klebsiella pneumoniae in a Neutropenic Murine Lung Infection Model

Antofloxacin is a novel broad-spectrum fluoroquinolone under development for the treatment of infections caused by a diverse group of bacterial species. We explored the pharmacodynamic (PD) profile and targets of antofloxacin against seven Klebsiella pneumoniae isolates by using a neutropenic murine...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Zhou, Yu-Feng, Tao, Meng-Ting, Huo, Wei, Liao, Xiao-Ping, Sun, Jian, Liu, Ya-Hong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404557/
https://ncbi.nlm.nih.gov/pubmed/28264844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02691-16
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