In Vivo Pharmacodynamic Target Assessment of Antofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a Neutropenic Murine Pneumonia Model

We determined in vivo efficacy and target PK/PD exposures of antofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in the murine pneumonia model. The mean plasma free drug area under the concentration-time curve/MIC (fAUC/MIC) targets associated with stasis and 1-log(10) and 2-log(...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Zhou, Yu-Feng, Liu, Ping, Dai, Shu-He, Sun, Jian, Liu, Ya-Hong, Liao, Xiao-Ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674040/
https://ncbi.nlm.nih.gov/pubmed/32928734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01354-20
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