Simplified Reversed Chloroquines To Overcome Malaria Resistance to Quinoline-Based Drugs

Building on our earlier work of attaching a chemosensitizer (reversal agent) to a known drug pharmacophore, we have now expanded the structure-activity relationship study to include simplified versions of the chemosensitizer. The change from two aromatic rings in this head group to a single ring doe...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Autores principales: Gunsaru, Bornface, Burgess, Steven J., Morrill, Westin, Kelly, Jane X., Shomloo, Shawheen, Smilkstein, Martin J., Liebman, Katherine, Peyton, David H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2017
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404532/
https://ncbi.nlm.nih.gov/pubmed/28193646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01913-16
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