Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis

OBJECTIVE: Alterations in sphingolipid and ceramide metabolism have been associated with various diseases, including nonalcoholic fatty liver disease (NAFLD). Acid sphingomyelinase (ASM) converts the membrane lipid sphingomyelin to ceramide, thereby affecting membrane composition and domain formatio...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Sydor, Svenja, Sowa, Jan-Peter, Megger, Dominik A., Schlattjan, Martin, Jafoui, Sami, Wingerter, Lena, Carpinteiro, Alexander, Baba, Hideo A., Bechmann, Lars P., Sitek, Barbara, Gerken, Guido, Gulbins, Erich, Canbay, Ali
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404101/
https://ncbi.nlm.nih.gov/pubmed/28462076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.03.002
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