Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing

OBJECTIVE: Arcuate proopiomelanocortin (POMC) neurons are critical nodes in the control of body weight. Often characterized simply as direct targets for leptin, recent data suggest a more complex architecture. METHODS: Using single cell RNA sequencing, we have generated an atlas of gene expression i...

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Pubblicato in:Mol Metab
Autori principali: Lam, Brian Y.H., Cimino, Irene, Polex-Wolf, Joseph, Nicole Kohnke, Sara, Rimmington, Debra, Iyemere, Valentine, Heeley, Nicholas, Cossetti, Chiara, Schulte, Reiner, Saraiva, Luis R., Logan, Darren W., Blouet, Clemence, O'Rahilly, Stephen, Coll, Anthony P., Yeo, Giles S.H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404100/
https://ncbi.nlm.nih.gov/pubmed/28462073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.02.007
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